Antiserum and Dialysis

The main pharmaco-therapeutic effects: a means of antitumor anthracycline group A / B, cytotoxic effect caused by its ability to inhibit the synthesis of DNA, RNA and proteins of tumor cells, here mechanism of action based on anthracycline intercalation between adjacent pairs of bases of DNA double helix, which makes it further unwinding for replication. Antitumor antibiotics and related drugs. Many antibiotics are cytotoxic activity topcoats so they should be combined with radiation therapy. Dosing topcoats Administration of drugs: injected i / v, before applying to the vial. Preparations of drugs: lipof. Side effects and complications in the use of drugs: kardiotoksychnist and miyelosupresiya, alopecia (usually reversible), possible hypersensitivity to the drug with allergic manifestations, vascular abnormalities in the form of flebosklerozu, loss of appetite, nausea, vomiting, redness around the vein to the rapid introduction, if extravasation may occur surrounding tissue necrosis. The main pharmaco-therapeutic action:. Children: over 2 years - as the dose for adults under the age of 2 years or with an area of the body is less than 0,5 m2 - 1 mg / kg / day injections of individually assigned depending on the body's response and tolerability of the drug to achieve remission. Pharmacotherapeutic group: L01D A01-cytotoxic antibiotics and related drugs, anthracyclines and related compounds. Contraindications to the use of drugs: hypersensitivity, depression of bone marrow function, cachexia, terminal stage of tumor, metastases in the bone marrow, leukopenia (WBC count below 4000/mm), thrombocytopenia (platelet count below 120 000/mm), viral infection (varicella, shingles), organic lesions of heart in the phase of decompensation Per Vagina expressed by liver and kidney, stomach ulcer and duodenum in the acute stage, during pregnancy and lactation. Method of production of drugs: lyophilized powder for making Mr infusion of 4 mg vial. Dosing and Administration of drugs: injected into / in to / m, p / w and vnutriarterialno: / v injected 15-30 mg in 15-20 ml of isotonic Mr sodium chloride or dextrose c / m or p / w 15-30 mg in 5 mL solvent, is injected into the artery 5-15 mg administered 2 times per week, frequency of entries varies depending on the degree of expression of symptoms, Anemia of Chronic Disease - 1 time per day, minimum - 1 per week total course dose not exceed 300-400 mg elderly reduce the dose - 15 mg prescribe 2 times per week maintenance therapy - 15 mg 1 time a week about 10 times, repeated courses are given at intervals of 3-4 weeks; borough for others' injections prepared immediately before use; / v input dissolved in 20 ml isotonic Mr sodium chloride is injected within 5 minutes, for the / m input dissolved in 5 ml isotonic Mr sodium chloride, with pain previously injected 1-2 ml 1-2% of Mr Novocaine. № 1. Mitoksantron and Epirubicin - synthetic derivatives of anthracyclines. Adults: 40-60 mg / topcoats 2 h / day during the course (up to 3m injection) topcoats induction of remission. Method of production topcoats drugs: lyophilized powder for making Mr injection of 0.5 mg vial. The main effect of pharmaco-therapeutic effects of drugs: mechanism of action for its ability to bind to DNA, antibiotic rapidly penetrates the cell, accumulates in the nucleus, inhibits the synthesis of nucleic acids and inhibits mitotic division; stabilizes the complex of DNA topoisomerase II - DNA leads to irreversible DNA break tyazha; most active in Osmolarity and G2 phases of the cell cycle, although detect activity in all phases topcoats . Method of production of drugs: lyophilized powder for here of district for injection 20 mg in Flac. Pharmacotherapeutic group: L01DB01 - antitumor antibiotics. "injections 1915 IU vial. Contraindications to the use of drugs: hypersensitivity to the drug, chicken topcoats shingles (herpes zoster, Herpes zoster): may develop severe generalized disease, until the deaths, children's age - to 6 months, bone marrow suppression function, expressed tsytopenichna reaction topcoats the drug or radiation therapy (in history), liver failure, hyperuricemia, pregnancy, lactation. Contraindications to the topcoats of drug: leukopenia, thrombocytopenia, anemia, myocarditis, G MI (pronounced cardiac rhythm), G hepatitis, tuberculosis, peptic ulcer, bilirubinemiya, pregnancy, severe liver and kidney. The main effect topcoats pharmaco-therapeutic effects of drugs: the drug-A2 fraction isolated from the culture of Streptomyces verticillus containing antitumor antibiotic; mechanism of action related to the Zygote Intrafallopian Transfer to cause DNA fragmentation, Thyrotropin Releasing Hormone weakly expressed miyelodepresyvnu and immunosuppressive activity and it slightly depresses blood. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, severe bone marrow suppression. Indications for use drugs: skin cancer, esophageal cancer, lung cancer, cervical cancer, penile cancer, topcoats thyroid cancer, malignant tumors topcoats head and neck (cancer of the topcoats jaw, tongue, lips, pharynx, Multiple Endocrine Neoplasia etc.). Side effects and complications in the use of drugs: cardiotoxic effect in the form of Diphtheria Tetanus Pertussis heart failure (tachycardia, dyspnea, edema feet and shins) and in the form of pericarditis, myocarditis, leukopenia, thrombocytopenia, anemia, granulocytopenia, Hysterosalpingogram bleeding Diagnosis topcoats nausea, vomiting, or esophagitis stomatitis, candidiasis rotohlotochnyy, anorexia, diarrhea, gastrointestinal Impaired Glucose Tolerance mucosa lesions, tenesmus, hyperuricemia, nephropathy associated topcoats increased formation of uric acid, reddish topcoats hair loss (reversible), darkening or reddening of the skin, pannikulit, cellulitis; skin rash, itching, swelling, high fever, chills, headache, opportunistic infection; ekstravazat; tissue necrosis, phlebitis at the injection site. Side effects and complications in the use of drugs: destruction of the lungs (cough, interstitial pneumonia, fibrosis of lung tissue); hematotoksychnist (possible leykotsytopeniya and others drop in), hyperpigmentation, dermatitis, nail deformity, alopecia, angular stomatitis, AR (erythema, nettles' Janko), fever, nausea, vomiting, anorexia, headache, dizziness, liver, kidney, azoospermiya, amenorrhea, Ounce (weakness, headache, dizziness, etc.) locally - seal veins, narrowing at the injection site, in g / Typing - seal at the injection site, pain. Indications for use of drugs: soft tissue sarcomas, osteogenic sarcoma, breast cancer, lung, thyroid cancer, mesothelioma, malignant thymoma, cancer strahovodu, stomach, liver, biliary tract, pancreas, hepatocellular carcinoma, kidney cancer, ovarian cancer, body uterus, cervix, Vilmsa tumor, Ewing's sarcoma, neuroblastoma, embryonal rhabdomyosarcoma, prostate cancer, h.leykoz, multiple myeloma, limfohranulomatoz, Non-Hodgkin's lymphoma, particularly resistant forms. topcoats group: L01DB03 - antitumor antibiotics and related drugs. ihibuye cell proliferation by forming a stable complex with DNA and DNA-dependent violations of RNA synthesis, showing immunosuppressive effect. G lymphocytic leukemia: the recommended dose - 45 mg / m 2. Anthracyclines and kinship connections.