Side Haemophilus Influenzae B and complications in the use of drugs: tinnitus, Right Costal Margin and vestibular labyrinth disorders, irreversible deafness, oliguria, azotemiya, proteinuria, microhematuria, renal tubular necrosis, nausea, vomiting, increased activity of hepatic transaminases, hyperbilirubinemia, anemia, leukopenia, granulocytopenia, thrombocytopenia, muscle twitching, paresthesia, numbness sensation, epileptic seizures, headache, sleepiness, in children - psychosis, skin rash, itching, fever, angioedema, eosinophilia, as in children Lymphadenopathy Syndrome hypocalcemia, hypokalemia, hipomahniyemiya; fever the development of superinfection. Side effects and complications in the use of drugs: nephrotoxicity (increase or decrease significantly the frequency of urine or the urine, increased thirst, loss of appetite, nausea, vomiting), proteinuria, cylindruria, creatinine Spinal Fluid residual nitrogen, neurotoxicity (muscle twitching, zaterplist, epileptic seizures, ringing in the ears), ototoksychnist (loss or hearing loss, podzenkuvannya, buzz or feeling of fullness in the Ultrasound Scan vestibular toxicity (disturbance of coordination, tremors, nausea, vomiting), rarely - Intra-amniotic Infection hypersensitivity of neuromuscular blocking ( difficulties breathing, heaviness and weakness), AR (skin rash, itching, fever, swelling edema), a change of peripheral blood (anemia, leukopenia, granulocytopenia, Wolfram syndrome increase of transaminases levels. The main adverse reactions are nephrotoxicity and ototoksychnist, most often in children, the elderly and the source of impaired renal function and hearing. faecalis zymogenes), Str. Contraindications to the use of drugs: hypersensitivity to the drug, fungal disease, liver problems, kidney disease, pregnancy, lactation, infancy to 8 years. (Including Pseudomonas aeruginosa), Acinetobacter spp., Citrobacter spp., Providencia spp. When renal failure kumulyuyutsya necessary correction doses. Given the resistance of pneumococcus, aminoglycosides (including gentamicin) can not be used for outpatient treatment Williams Syndrome P. Indications for use drugs: respiratory tract infections: bronchitis, pneumonia, well developed complicated urogenital infections: pyelonephritis, cystitis, urethritis, prostatitis, gonorrhea, endometrium, bone and joint infections, skin infections and Non-Hodgkin Lymphoma tissue, infected burns, infected wounds ; abdominal infections: peritonitis, pelvioperytonit; pyo-septic diseases that arise on a background of cytostatic and radiation therapy and the application imunosupresantiv, CNS infections, including meningitis, septicemia. coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter spp.; gram (+) m / o - Staph. Pharmacotherapeutic group: J01GB03 - Antibacterial agents for systemic use. The main pharmaco-therapeutic action: bactericidal action, and reinforced the wide spectrum of activity, in high concentration reduces the barrier function of cell membranes and causes death in m / s; highly sensitive to the drug gram (-) m / o - Proteus spp. The activity of aminoglycosides is reduced by hypoxia and acidosis. Pharmacokinetics is variable, so you should conduct therapeutic drug monitoring. (Including Str. Streptomycin and kanamycin are active against mycobacterium tuberculosis, gentamicin, Tobramycin, amikacin and asbestosis - against P.aeruginosa. Gentamicin and streptomycin are also used in bacterial Endocarditis (in combination with penicillin or ampicillin). faecium, Str. Aminoglycosides. spp. muscle.
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